A Sparse Bayesian Learning Algorithm for White Matter Parameter Estimation from Compressed Multi-shell Diffusion MRI.

Conference Paper

We propose a sparse Bayesian learning algorithm for improved estimation of white matter fiber parameters from compressed (under-sampled q-space) multi-shell diffusion MRI data. The multi-shell data is represented in a dictionary form using a non-monoexponential decay model of diffusion, based on continuous gamma distribution of diffusivities. The fiber volume fractions with predefined orientations, which are the unknown parameters, form the dictionary weights. These unknown parameters are estimated with a linear un-mixing framework, using a sparse Bayesian learning algorithm. A localized learning of hyperparameters at each voxel and for each possible fiber orientations improves the parameter estimation. Our experiments using synthetic data from the ISBI 2012 HARDI reconstruction challenge and in-vivo data from the Human Connectome Project demonstrate the improvements.

Full Text

Duke Authors

Cited Authors

  • Pisharady, PK; Sotiropoulos, SN; Sapiro, G; Lenglet, C

Published Date

  • September 4, 2017

Published In

  • Medical Image Computing and Computer Assisted Intervention : Miccai ... International Conference on Medical Image Computing and Computer Assisted Intervention

Volume / Issue

  • 10433 /

Start / End Page

  • 602 - 610

PubMed ID

  • 29104968

Pubmed Central ID

  • PMC5667569

Digital Object Identifier (DOI)

  • 10.1007/978-3-319-66182-7_69