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Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study.

Publication ,  Journal Article
Sobrin, L; Chong, YH; Fan, Q; Gan, A; Stanwyck, LK; Kaidonis, G; Craig, JE; Kim, J; Liao, W-L; Huang, Y-C; Lee, W-J; Hung, Y-J; Guo, X ...
Published in: Diabetes
December 2017

Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach. We pooled genome-wide association studies summary statistics from 18 studies for two DR phenotypes: any DR (N = 2,969 case and 4,096 control subjects) and severe DR (N = 1,277 case and 3,980 control subjects). Previously identified lipid-associated single nucleotide polymorphisms served as instrumental variables. Meta-analysis to combine the Mendelian randomization estimates from different cohorts was conducted. There was no statistically significant change in odds ratios of having any DR or severe DR for any of the lipid fractions in the primary analysis that used single nucleotide polymorphisms that did not have a pleiotropic effect on another lipid fraction. Similarly, there was no significant association in the Caucasian and Chinese subgroup analyses. This study did not show evidence of a causal role of the four lipid fractions on DR. However, the study had limited power to detect odds ratios less than 1.23 per SD in genetically induced increase in plasma lipid levels, thus we cannot exclude that causal relationships with more modest effect sizes exist.

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Published In

Diabetes

DOI

EISSN

1939-327X

Publication Date

December 2017

Volume

66

Issue

12

Start / End Page

3130 / 3141

Location

United States

Related Subject Headings

  • Risk
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Mendelian Randomization Analysis
  • Male
  • Lipids
  • Humans
  • Genome-Wide Association Study
  • Female
  • Endocrinology & Metabolism
 

Citation

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Chicago
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Sobrin, L., Chong, Y. H., Fan, Q., Gan, A., Stanwyck, L. K., Kaidonis, G., … Cheng, C.-Y. (2017). Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes, 66(12), 3130–3141. https://doi.org/10.2337/db17-0398
Sobrin, Lucia, Yong He Chong, Qiao Fan, Alfred Gan, Lynn K. Stanwyck, Georgia Kaidonis, Jamie E. Craig, et al. “Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study.Diabetes 66, no. 12 (December 2017): 3130–41. https://doi.org/10.2337/db17-0398.
Sobrin L, Chong YH, Fan Q, Gan A, Stanwyck LK, Kaidonis G, et al. Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes. 2017 Dec;66(12):3130–41.
Sobrin, Lucia, et al. “Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study.Diabetes, vol. 66, no. 12, Dec. 2017, pp. 3130–41. Pubmed, doi:10.2337/db17-0398.
Sobrin L, Chong YH, Fan Q, Gan A, Stanwyck LK, Kaidonis G, Craig JE, Kim J, Liao W-L, Huang Y-C, Lee W-J, Hung Y-J, Guo X, Hai Y, Ipp E, Pollack S, Hancock H, Price A, Penman A, Mitchell P, Liew G, Smith AV, Gudnason V, Tan G, Klein BEK, Kuo J, Li X, Christiansen MW, Psaty BM, Sandow K, Asian Genetic Epidemiology Network Consortium, Jensen RA, Klein R, Cotch MF, Wang JJ, Jia Y, Chen CJ, Chen Y-DI, Rotter JI, Tsai F-J, Hanis CL, Burdon KP, Wong TY, Cheng C-Y. Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes. 2017 Dec;66(12):3130–3141.

Published In

Diabetes

DOI

EISSN

1939-327X

Publication Date

December 2017

Volume

66

Issue

12

Start / End Page

3130 / 3141

Location

United States

Related Subject Headings

  • Risk
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Mendelian Randomization Analysis
  • Male
  • Lipids
  • Humans
  • Genome-Wide Association Study
  • Female
  • Endocrinology & Metabolism