Nontarget Screening with High Resolution Mass Spectrometry in the Environment: Ready to Go?

Journal Article (Journal Article)

The vast, diverse universe of organic pollutants is a formidable challenge for environmental sciences, engineering, and regulation. Nontarget screening (NTS) based on high resolution mass spectrometry (HRMS) has enormous potential to help characterize this universe, but is it ready to go for real world applications? In this Feature article we argue that development of mass spectrometers with increasingly high resolution and novel couplings to both liquid and gas chromatography, combined with the integration of high performance computing, have significantly widened our analytical window and have enabled increasingly sophisticated data processing strategies, indicating a bright future for NTS. NTS has great potential for treatment assessment and pollutant prioritization within regulatory applications, as highlighted here by the case of real-time pollutant monitoring on the River Rhine. We discuss challenges for the future, including the transition from research toward solution-centered and robust, harmonized applications.

Full Text

Duke Authors

Cited Authors

  • Hollender, J; Schymanski, EL; Singer, HP; Ferguson, PL

Published Date

  • October 2017

Published In

Volume / Issue

  • 51 / 20

Start / End Page

  • 11505 - 11512

PubMed ID

  • 28877430

Electronic International Standard Serial Number (EISSN)

  • 1520-5851

International Standard Serial Number (ISSN)

  • 0013-936X

Digital Object Identifier (DOI)

  • 10.1021/acs.est.7b02184


  • eng