Preliminary study of quinine pharmacokinetics in pregnant women with malaria-HIV co-infection.

Journal Article

Pregnant women bear the greatest burden of malaria-human immunodeficiency virus co-infection. Previous studies suggest that interaction with antiretroviral drugs may compromise antimalarial pharmacokinetics and treatment outcomes. We conducted a preliminary clinical study to assess quinine pharmacokinetics in Malian pregnant women with acute malaria who reported taking nevirapine-based antiretroviral therapy. Of seven women, six had stable concentrations of nevirapine in the plasma and one had none. Quinine concentrations were lower, and its metabolite 3-hydroxyquinine higher, in the six women with nevirapine than in the one without, and quinine concentrations were below the recommended therapeutic range in 50% of the women. This preliminary observation warrants further research to understand the impact of long-term antiretroviral therapy on the treatment of acute malaria.

Full Text

Duke Authors

Cited Authors

  • Kayentao, K; Guirou, EA; Doumbo, OK; Venkatesan, M; Plowe, CV; Parsons, TL; Hendrix, CW; Nyunt, MM

Published Date

  • March 2014

Published In

Volume / Issue

  • 90 / 3

Start / End Page

  • 530 - 534

PubMed ID

  • 24420779

Electronic International Standard Serial Number (EISSN)

  • 1476-1645

International Standard Serial Number (ISSN)

  • 0002-9637

Digital Object Identifier (DOI)

  • 10.4269/ajtmh.13-0655


  • eng