Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.


Journal Article

Combination drug therapy for malaria is recommended both to prevent and to overcome drug resistance. Drug combinations developed for use in Asia are being deployed in Africa, where higher rates of malaria affect the therapeutic and public health objectives of malaria chemotherapy as well as drug safety. Rational consideration of drug mechanisms, pharmacokinetics (PK), pharmacodynamics (PD), and malaria epidemiology should result in more effective combination regimens that retain therapeutic and prophylactic efficacy in the face of resistance.

Full Text

Duke Authors

Cited Authors

  • Nyunt, MM; Plowe, CV

Published Date

  • November 2007

Published In

Volume / Issue

  • 82 / 5

Start / End Page

  • 601 - 605

PubMed ID

  • 17898709

Pubmed Central ID

  • 17898709

Electronic International Standard Serial Number (EISSN)

  • 1532-6535

Digital Object Identifier (DOI)

  • 10.1038/sj.clpt.6100361


  • eng

Conference Location

  • United States