The case for strategic international alliances to harness nutritional genomics for public and personal health.


Journal Article (Review)

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

Full Text

Duke Authors

Cited Authors

  • Kaput, J; Ordovas, JM; Ferguson, L; van Ommen, B; Rodriguez, RL; Allen, L; Ames, BN; Dawson, K; German, B; Krauss, R; Malyj, W; Archer, MC; Barnes, S; Bartholomew, A; Birk, R; van Bladeren, P; Bradford, KJ; Brown, KH; Caetano, R; Castle, D; Chadwick, R; Clarke, S; Clément, K; Cooney, CA; Corella, D; Manica da Cruz, IB; Daniel, H; Duster, T; Ebbesson, SOE; Elliott, R; Fairweather-Tait, S; Felton, J; Fenech, M; Finley, JW; Fogg-Johnson, N; Gill-Garrison, R; Gibney, MJ; Gillies, PJ; Gustafsson, J-A; Hartman, JL; He, L; Hwang, J-K; Jais, J-P; Jang, Y; Joost, H; Junien, C; Kanter, M; Kibbe, WA; Koletzko, B; Korf, BR; Kornman, K; Krempin, DW; Langin, D; Lauren, DR; Ho Lee, J; Leveille, GA; Lin, S-J; Mathers, J; Mayne, M; McNabb, W; Milner, JA; Morgan, P; Muller, M; Nikolsky, Y; van der Ouderaa, F; Park, T; Pensel, N; Perez-Jimenez, F; Poutanen, K; Roberts, M; Saris, WHM; Schuster, G; Shelling, AN; Simopoulos, AP; Southon, S; Tai, ES; Towne, B; Trayhurn, P; Uauy, R; Visek, WJ; Warden, C; Weiss, R; Wiencke, J; Winkler, J; Wolff, GL; Zhao-Wilson, X; Zucker, J-D

Published Date

  • November 2005

Published In

Volume / Issue

  • 94 / 5

Start / End Page

  • 623 - 632

PubMed ID

  • 16277761

Pubmed Central ID

  • 16277761

International Standard Serial Number (ISSN)

  • 0007-1145

Digital Object Identifier (DOI)

  • 10.1079/bjn20051585


  • eng

Conference Location

  • England