Emerging therapeutics for ocular surface disease.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: The present review provides an overview on the potential of different systemic and topical treatments in chronic forms of ocular allergy and dry eye disorder (DED). The impact on anterior surface of ocular inflammatory disorder encompasses an array of conditions, which are frequently underreported. This can contribute to underdiagnoses and ineffective management from healthcare providers such as an allergist and/or ophthalmologist who routinely provide care for these common disorders. Owing to the current limited therapeutic options, healthcare providers are routinely seeking alternative treatments that could facilitate effective management of the conditions. RECENT FINDINGS: Recent advances in immunopathophysiology of ocular surface disorders has provided new potential targets and therapeutic strategies for the treatment of DED and ocular allergy that may include various immunobiological modulators. These modulators have focused on regulating the Th1 and Th2 immune-mediated inflammatory pathways that inhibit various cytokines (e.g. IL-1, IL-4, IL-5, IL-9, IL-13) antibodies (e.g. IgE), and other surface markers of various cell lines (e.g. activated T-lymphocytes, lymphocyte function-associated antigen-1). SUMMARY: Recent findings about the pathophysiology of DED and ocular allergy have led to the greater understanding of the molecular and cellular mechanisms of ocular surface diseases leading to the potential novel targets for immunomodulation of anterior surface ocular disorders. New topical glucocorticoids, leukotriene receptor antagonists, IL-1 antagonists, IL-5, IL-4/IL-13 antagonists, integrin antagonists, and quinolone derivatives appear to be encouraging.

Full Text

Duke Authors

Cited Authors

  • Bielory, BP; Shah, SP; O'Brien, TP; Perez, VL; Bielory, L

Published Date

  • October 2016

Published In

Volume / Issue

  • 16 / 5

Start / End Page

  • 477 - 486

PubMed ID

  • 27585059

Pubmed Central ID

  • 27585059

Electronic International Standard Serial Number (EISSN)

  • 1473-6322

Digital Object Identifier (DOI)

  • 10.1097/ACI.0000000000000309

Language

  • eng

Conference Location

  • United States