Endothelial graft failure after contralateral autologous corneal transplantation.
Journal Article
Purpose
To report on outcomes after contralateral autologous penetrating keratoplasty (APK).Design
Case series.Patient population
Five patients who received a contralateral APK and a simultaneous allogeneic penetrating keratoplasty in the donor eye at the Bascom Palmer Eye Institute and the Miami Veterans Affairs Hospital.Results
The median patient age at the time of surgery in our 5 patients was 67 years (range, 58-88 years); 4 patients were male and 1 female, and 1 patient was white and 4 were black. The surgery was uneventful in all cases, and no operative or immediate postoperative complications occurred in either eye. Follow-up time ranged from 18 to 54 months (mean, 35 months; median, 34 months). During this time, 4 of the autologous grafts failed because of endothelial attenuation. Identified risk factors for failure in the autologous eyes included the presence of a glaucoma tube (5/5), previous graft failure (4/5), and anterior synechiae (2/5).Conclusions
This study is the first to describe graft failure because of slow endothelial attenuation after APK. This study underscores the importance of nonimmunologic factors in endothelial cell loss after corneal transplant surgery and highlights the need for further research to understand and modulate endothelial loss.Full Text
Duke Authors
Cited Authors
- Martinez, JD; Galor, A; Perez, VL; Karp, CL; Yoo, SH; Alfonso, EC
Published Date
- June 2013
Published In
Volume / Issue
- 32 / 6
Start / End Page
- 745 - 750
PubMed ID
- 23132452
Pubmed Central ID
- 23132452
Electronic International Standard Serial Number (EISSN)
- 1536-4798
International Standard Serial Number (ISSN)
- 0277-3740
Digital Object Identifier (DOI)
- 10.1097/ico.0b013e31826dff17
Language
- eng