Stability of Th1 and Th2 populations.

Journal Article (Journal Article)

Using an in vitro model for the development of IFN-gamma-producing (Th1) and IL-4-producing (Th2) cells from CD4+ T lymphocytes expressing a transgenic TCR, we show that IL-12 and IL-4 are the most potent stimuli for the differentiation of naive T cells to effector populations. When combinations of cytokines are present during T cell priming, the effect of IL-4 is dominant. Furthermore, differentiated Th1 cells can be converted into IL-4 producers by exposure to IL-4, but the Th2 phenotype is not reversible. The stability of Th2 populations may limit the ability to regulate Th2-dominant responses in pathologic situations.

Full Text

Duke Authors

Cited Authors

  • Perez, VL; Lederer, JA; Lichtman, AH; Abbas, AK

Published Date

  • May 1995

Published In

Volume / Issue

  • 7 / 5

Start / End Page

  • 869 - 875

PubMed ID

  • 7547713

International Standard Serial Number (ISSN)

  • 0953-8178

Digital Object Identifier (DOI)

  • 10.1093/intimm/7.5.869


  • eng

Conference Location

  • England