Differentiation and tolerance of CD4+ T lymphocytes.

Journal Article (Journal Article;Review)

The development of effector and memory populations of T lymphocytes is determined by antigen-induced growth and differentiation of naive T cells, and it is regulated by antigen-induced functional tolerance and cell death. CD4+ helper T lymphocytes that vary in their profiles of cytokine production and in effector functions also show distinct responses to antigens and co-stimulatory signals, and they differ in their sensitivity to tolerance induction. Thus, stimuli that trigger T cell growth and differentiation, as well as mechanisms that inhibit T cell expansion, determine both the magnitude and the nature of T cell-dependent immune responses to protein antigens.

Full Text

Duke Authors

Cited Authors

  • Abbas, AK; Perez, VL; Van Parijs, L; Wong, RC

Published Date

  • 1995

Published In

Volume / Issue

  • 195 /

Start / End Page

  • 7 - 13

PubMed ID

  • 8724827

International Standard Serial Number (ISSN)

  • 0300-5208

Digital Object Identifier (DOI)

  • 10.1002/9780470514849.ch2


  • eng

Conference Location

  • Netherlands