Differentiation and tolerance of CD4+ T lymphocytes.
Journal Article (Journal Article;Review)
The development of effector and memory populations of T lymphocytes is determined by antigen-induced growth and differentiation of naive T cells, and it is regulated by antigen-induced functional tolerance and cell death. CD4+ helper T lymphocytes that vary in their profiles of cytokine production and in effector functions also show distinct responses to antigens and co-stimulatory signals, and they differ in their sensitivity to tolerance induction. Thus, stimuli that trigger T cell growth and differentiation, as well as mechanisms that inhibit T cell expansion, determine both the magnitude and the nature of T cell-dependent immune responses to protein antigens.
- Abbas, AK; Perez, VL; Van Parijs, L; Wong, RC
Volume / Issue
- 195 /
Start / End Page
- 7 - 13
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)