Bayesian spatial-temporal model for cardiac congenital anomalies and ambient air pollution risk assessment

Journal Article (Journal Article)

We introduce a Bayesian spatial-temporal hierarchical multivariate probit regression model that identifies weeks during the first trimester of pregnancy, which are impactful in terms of cardiac congenital anomaly development. The model is able to consider multiple pollutants and a multivariate cardiac anomaly grouping outcome jointly while allowing the critical windows to vary in a continuous manner across time and space. We utilize a dataset of numerical chemical model output that contains information regarding multiple species of PM . Our introduction of an innovative spatial-temporal semiparametric prior distribution for the pollution risk effects allows for greater flexibility to identify critical weeks during pregnancy, which are missed when more standard models are applied. The multivariate kernel stick-breaking prior is extended to include space and time simultaneously in both the locations and the masses in order to accommodate complex data settings. Simulation study results suggest that our prior distribution has the flexibility to outperform competitor models in a number of data settings. When applied to the geo-coded Texas birth data, weeks 3, 7 and 8 of the pregnancy are identified as being impactful in terms of cardiac defect development for multiple pollutants across the spatial domain. © 2012 John Wiley & Sons, Ltd. 2.5

Full Text

Duke Authors

Cited Authors

  • Warren, J; Fuentes, M; Herring, A; Langlois, P

Published Date

  • December 1, 2012

Published In

Volume / Issue

  • 23 / 8

Start / End Page

  • 673 - 684

Electronic International Standard Serial Number (EISSN)

  • 1099-095X

International Standard Serial Number (ISSN)

  • 1180-4009

Digital Object Identifier (DOI)

  • 10.1002/env.2174

Citation Source

  • Scopus