Consumer product exposures associated with urinary phthalate levels in pregnant women.

Journal Article (Journal Article)

Human phthalate exposure is ubiquitous, but little is known regarding predictors of urinary phthalate levels. To explore this, 50 pregnant women aged 18-38 years completed two questionnaires on potential phthalate exposures and provided a first morning void. Urine samples were analyzed for 12 phthalate metabolites. Associations with questionnaire items were evaluated via Wilcoxon tests and t-tests, and r-squared values were calculated in multiple linear regression models. Few measured factors were statistically significantly associated with phthalate levels. Individuals who used nail polish had higher levels of mono-butyl phthalate (P=0.048) than non-users. Mono-benzyl phthalate levels were higher among women who used eye makeup (P=0.034) or used makeup on a regular basis (P=0.004). Women who used cologne or perfume had higher levels of di-(2-ethylhexyl) phthalate metabolites. Household products, home flooring or paneling, and other personal care products were also associated with urinary phthalates. The proportion of variance in metabolite concentrations explained by questionnaire items ranged between 0.31 for mono-ethyl phthalate and 0.42 for mono-n-methyl phthalate. Although personal care product use may be an important predictor of urinary phthalate levels, most of the variability in phthalate exposure was not captured by our relatively comprehensive set of questionnaire items.

Full Text

Duke Authors

Cited Authors

  • Buckley, JP; Palmieri, RT; Matuszewski, JM; Herring, AH; Baird, DD; Hartmann, KE; Hoppin, JA

Published Date

  • September 2012

Published In

Volume / Issue

  • 22 / 5

Start / End Page

  • 468 - 475

PubMed ID

  • 22760436

Pubmed Central ID

  • PMC3439834

Electronic International Standard Serial Number (EISSN)

  • 1559-064X

International Standard Serial Number (ISSN)

  • 1559-0631

Digital Object Identifier (DOI)

  • 10.1038/jes.2012.33


  • eng