Detecting disease outbreaks using local spatiotemporal methods.
Journal Article (Journal Article)
A real-time surveillance method is developed with emphasis on rapid and accurate detection of emerging outbreaks. We develop a model with relatively weak assumptions regarding the latent processes generating the observed data, ensuring a robust prediction of the spatiotemporal incidence surface. Estimation occurs via a local linear fitting combined with day-of-week effects, where spatial smoothing is handled by a novel distance metric that adjusts for population density. Detection of emerging outbreaks is carried out via residual analysis. Both daily residuals and AR model-based detrended residuals are used for detecting abnormalities in the data given that either a large daily residual or an increasing temporal trend in the residuals signals a potential outbreak, with the threshold for statistical significance determined using a resampling approach.
Full Text
Duke Authors
Cited Authors
- Zhao, Y; Zeng, D; Herring, AH; Ising, A; Waller, A; Richardson, D; Kosorok, MR
Published Date
- December 2011
Published In
Volume / Issue
- 67 / 4
Start / End Page
- 1508 - 1517
PubMed ID
- 21418049
Pubmed Central ID
- PMC3698245
Electronic International Standard Serial Number (EISSN)
- 1541-0420
International Standard Serial Number (ISSN)
- 0006-341X
Digital Object Identifier (DOI)
- 10.1111/j.1541-0420.2011.01585.x
Language
- eng