Frailty models with missing covariates.

Journal Article (Journal Article)

We present a method for estimating the parameters in random effects models for survival data when covariates are subject to missingness. Our method is more general than the usual frailty model as it accommodates a wide range of distributions for the random effects, which are included as an offset in the linear predictor in a manner analogous to that used in generalized linear mixed models. We propose using a Monte Carlo EM algorithm along with the Gibbs sampler to obtain parameter estimates. This method is useful in reducing the bias that may be incurred using complete-case methods in this setting. The methodology is applied to data from Eastern Cooperative Oncology Group melanoma clinical trials in which observations were believed to be clustered and several tumor characteristics were not always observed.

Full Text

Duke Authors

Cited Authors

  • Herring, AH; Ibrahim, JG; Lipsitz, SR

Published Date

  • March 2002

Published In

Volume / Issue

  • 58 / 1

Start / End Page

  • 98 - 109

PubMed ID

  • 11890332

Electronic International Standard Serial Number (EISSN)

  • 1541-0420

International Standard Serial Number (ISSN)

  • 0006-341X

Digital Object Identifier (DOI)

  • 10.1111/j.0006-341x.2002.00098.x


  • eng