Bayesian modeling of multiple episode occurrence and severity with a terminating event.

Published

Journal Article

An individual's health condition can affect the frequency and intensity of episodes that can occur repeatedly and that may be related to an event time of interest. For example, bleeding episodes during pregnancy may indicate problems predictive of preterm delivery. Motivated by this application, we propose a joint model for a multiple episode process and an event time. The frequency of occurrence and severity of the episodes are characterized by a latent variable model, which allows an individual's episode intensity to change dynamically over time. This latent episode intensity is then incorporated as a predictor in a discrete time model for the terminating event. Time-varying coefficients are used to distinguish among effects earlier versus later in gestation. Formulating the model within a Bayesian framework, prior distributions are chosen so that conditional posterior distributions are conjugate after data augmentation. Posterior computation proceeds via an efficient Gibbs sampling algorithm. The methods are illustrated using bleeding episode and gestational length data from a pregnancy study.

Full Text

Duke Authors

Cited Authors

  • Herring, AH; Yang, J

Published Date

  • June 2007

Published In

Volume / Issue

  • 63 / 2

Start / End Page

  • 381 - 388

PubMed ID

  • 17688490

Pubmed Central ID

  • 17688490

Electronic International Standard Serial Number (EISSN)

  • 1541-0420

International Standard Serial Number (ISSN)

  • 0006-341X

Digital Object Identifier (DOI)

  • 10.1111/j.1541-0420.2006.00720.x

Language

  • eng