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Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study.

Publication ,  Journal Article
Laughlin, SK; Baird, DD; Savitz, DA; Herring, AH; Hartmann, KE
Published in: Obstetrics and gynecology
March 2009

To estimate the proportion of pregnant women with one or more leiomyomas detected by research-quality ultrasound screening in the first trimester, to describe the size and location of leiomyomas identified, and to report variation in prevalence by race/ethnicity.Within an ongoing prospective cohort, we conducted 4,271 first-trimester or postmiscarriage ultrasound examinations. Sonographers measured each leiomyoma three separate times, recording the maximum diameter in three perpendicular planes each time. Sonographers and investigators classified type and location.Among 458 women with one or more leiomyomas (prevalence 10.7%), we identified a total of 687 leiomyomas. The mean size of the largest leiomyoma was 2.3 cm (95% confidence interval [CI] 1.8-2.8). Mean gestational age at ultrasonography was 61+/-13 days from last menstrual period. Prevalence varied by race/ethnicity: 18% in African-American women (95% CI 13-25), 8% in white women (95% CI 7-11), and 10% in Hispanic women (95% CI 5-19). The proportion of women with leiomyomas increased with age much more steeply for African-American women than for white women.Leiomyomas are common in pregnancy and occur more often among African-American women. Given the limited research on effects of leiomyomas on reproductive outcomes, the degree to which race/ethnic disparities in prevalence of leiomyomas may contribute to disparities in events such as miscarriage and preterm birth warrants investigation.

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Published In

Obstetrics and gynecology

DOI

EISSN

1873-233X

ISSN

0029-7844

Publication Date

March 2009

Volume

113

Issue

3

Start / End Page

630 / 635

Related Subject Headings

  • Uterine Neoplasms
  • Ultrasonography, Prenatal
  • Prevalence
  • Pregnancy Trimester, First
  • Pregnancy Complications, Neoplastic
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Leiomyoma
  • Humans
  • Female
 

Citation

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Laughlin, S. K., Baird, D. D., Savitz, D. A., Herring, A. H., & Hartmann, K. E. (2009). Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study. Obstetrics and Gynecology, 113(3), 630–635. https://doi.org/10.1097/aog.0b013e318197bbaf
Laughlin, Shannon K., Donna D. Baird, David A. Savitz, Amy H. Herring, and Katherine E. Hartmann. “Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study.Obstetrics and Gynecology 113, no. 3 (March 2009): 630–35. https://doi.org/10.1097/aog.0b013e318197bbaf.
Laughlin SK, Baird DD, Savitz DA, Herring AH, Hartmann KE. Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study. Obstetrics and gynecology. 2009 Mar;113(3):630–5.
Laughlin, Shannon K., et al. “Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study.Obstetrics and Gynecology, vol. 113, no. 3, Mar. 2009, pp. 630–35. Epmc, doi:10.1097/aog.0b013e318197bbaf.
Laughlin SK, Baird DD, Savitz DA, Herring AH, Hartmann KE. Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study. Obstetrics and gynecology. 2009 Mar;113(3):630–635.

Published In

Obstetrics and gynecology

DOI

EISSN

1873-233X

ISSN

0029-7844

Publication Date

March 2009

Volume

113

Issue

3

Start / End Page

630 / 635

Related Subject Headings

  • Uterine Neoplasms
  • Ultrasonography, Prenatal
  • Prevalence
  • Pregnancy Trimester, First
  • Pregnancy Complications, Neoplastic
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Leiomyoma
  • Humans
  • Female