Second trimester folate status and preterm birth.

Journal Article (Journal Article)


The purpose of this study was to show that maternal folate status during pregnancy may be related to preterm birth.

Study design

Women were recruited at 24 to 29 weeks' gestation from 1995 to 2000 into the Pregnancy, Infection, and Nutrition Study. Those who completed an interview and a food frequency questionnaire, or provided a blood sample for radioassay of serum (n = 2026) and red blood cell (n = 1034) folate were included.


Mean daily dietary folate intake was 463 microg (SD +/- 248). Intake ConclusionThese results support the hypothesis that low folate levels during the second trimester of pregnancy are associated with an increased risk of preterm birth.

Full Text

Duke Authors

Cited Authors

  • Siega-Riz, AM; Savitz, DA; Zeisel, SH; Thorp, JM; Herring, A

Published Date

  • December 2004

Published In

Volume / Issue

  • 191 / 6

Start / End Page

  • 1851 - 1857

PubMed ID

  • 15592264

Electronic International Standard Serial Number (EISSN)

  • 1097-6868

International Standard Serial Number (ISSN)

  • 0002-9378

Digital Object Identifier (DOI)

  • 10.1016/j.ajog.2004.07.076


  • eng