Complex structure and regulation of the P16 (MTS1) locus.


Journal Article

The p16 gene (P16, MTS1, CDKN2) encodes a negative regulator of the cell cycle. Molecular genetic techniques have been used to explore the role of p16 in normal development and cancer. Two transcripts derived from the p16 gene with distinct protein coding potentials are described. The previously undescribed transcript form has the same exons 2 and 3 as the p16-encoding mRNA but contains a different exon 1. The human p16 transcripts are detected in various tissues, and the ratio of the transcripts is regulated in both a tissue-specific and cell cycle-specific manner. The P16-derived mRNAs are probably generated from separate promoters, and transcription from one of the promoters appears to be regulated, at least in part, by the retinoblastoma gene product.

Full Text

Cited Authors

  • Stone, S; Jiang, P; Dayananth, P; Tavtigian, SV; Katcher, H; Parry, D; Peters, G; Kamb, A

Published Date

  • July 1995

Published In

Volume / Issue

  • 55 / 14

Start / End Page

  • 2988 - 2994

PubMed ID

  • 7606716

Pubmed Central ID

  • 7606716

Electronic International Standard Serial Number (EISSN)

  • 1538-7445

International Standard Serial Number (ISSN)

  • 0008-5472


  • eng