A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.


Journal Article

A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predisposing mutations have been detected in five of eight kindreds presumed to segregate BRCA1 susceptibility alleles. The mutations include an 11-base pair deletion, a 1-base pair insertion, a stop codon, a missense substitution, and an inferred regulatory mutation. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a zinc finger domain in its amino-terminal region, but is otherwise unrelated to previously described proteins. Identification of BRCA1 should facilitate early diagnosis of breast and ovarian cancer susceptibility in some individuals as well as a better understanding of breast cancer biology.

Full Text

Cited Authors

  • Miki, Y; Swensen, J; Shattuck-Eidens, D; Futreal, PA; Harshman, K; Tavtigian, S; Liu, Q; Cochran, C; Bennett, LM; Ding, W

Published Date

  • October 1994

Published In

Volume / Issue

  • 266 / 5182

Start / End Page

  • 66 - 71

PubMed ID

  • 7545954

Pubmed Central ID

  • 7545954

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.7545954


  • eng