Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children.

Journal Article (Journal Article;Multicenter Study)

OBJECTIVES: To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD. STUDY DESIGN: A multicenter, cross-sectional study of children with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network Database. Birth weight was categorized as low birth weight (LBW), normal birth weight (NBW), or high birth weight (HBW) and compared with the birth weight distribution in the general US population. The severity of liver histology was assessed by birth weight category. RESULTS: Children with NAFLD (n = 538) had overrepresentation of both LBW and HBW compared with the general US population (LBW, 9.3%; NBW, 75.8%; HBW, 14.9% vs LBW, 6.1%; NBW, 83.5%; HBW 10.5%; P < .0001). Children with HBW had significantly greater odds of having more severe steatosis (OR, 1.82, 95% CI. 1.15-2.88) and nonalcoholic steatohepatitis (OR, 2.03; 95% CI, 1.21-3.40) compared with children with NBW. In addition, children with NAFLD and LBW had significantly greater odds of having advanced fibrosis (OR, 2.23; 95% CI, 1.08-4.62). CONCLUSION: Birth weight involves maternal and in utero factors that may have long-lasting consequences. Children with both LBW and HBW may be at increased risk for developing NAFLD. Among children with NAFLD, those with LBW or HBW appear to be at increased risk for more severe disease.

Full Text

Duke Authors

Cited Authors

  • Newton, KP; Feldman, HS; Chambers, CD; Wilson, L; Behling, C; Clark, JM; Molleston, JP; Chalasani, N; Sanyal, AJ; Fishbein, MH; Lavine, JE; Schwimmer, JB; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN),

Published Date

  • August 2017

Published In

Volume / Issue

  • 187 /

Start / End Page

  • 141 - 146.e1

PubMed ID

  • 28366357

Pubmed Central ID

  • PMC5533631

Electronic International Standard Serial Number (EISSN)

  • 1097-6833

Digital Object Identifier (DOI)

  • 10.1016/j.jpeds.2017.03.007


  • eng

Conference Location

  • United States