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Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults.

Publication ,  Journal Article
Miller, JA; Scult, MA; Conley, ED; Chen, Q; Weinberger, DR; Hariri, AR
Published in: Schizophrenia bulletin
June 2018

Recent work has begun to shed light on the neural correlates and possible mechanisms of polygenic risk for schizophrenia. Here, we map a schizophrenia polygenic risk profile score (PRS) based on genome-wide association study significant loci onto variability in the activity and functional connectivity of a frontoparietal network supporting the manipulation versus maintenance of information during a numerical working memory (WM) task in healthy young adults (n = 99, mean age = 19.8). Our analyses revealed that higher PRS was associated with hypoactivity of the dorsolateral prefrontal cortex (dlPFC) during the manipulation but not maintenance of information in WM (r2 = .0576, P = .018). Post hoc analyses revealed that PRS-modulated dlPFC hypoactivity correlated with faster reaction times during WM manipulation (r2 = .0967, P = .002), and faster processing speed (r2 = .0967, P = .003) on a separate behavioral task. These PRS-associated patterns recapitulate dlPFC hypoactivity observed in patients with schizophrenia during central executive manipulation of information in WM on this task.

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Published In

Schizophrenia bulletin

DOI

EISSN

1745-1701

ISSN

1787-9965

Publication Date

June 2018

Volume

44

Issue

4

Start / End Page

844 / 853

Related Subject Headings

  • Young Adult
  • Schizophrenia
  • Psychiatry
  • Prefrontal Cortex
  • Multifactorial Inheritance
  • Memory, Short-Term
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Genome-Wide Association Study
 

Citation

APA
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ICMJE
MLA
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Miller, J. A., Scult, M. A., Conley, E. D., Chen, Q., Weinberger, D. R., & Hariri, A. R. (2018). Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults. Schizophrenia Bulletin, 44(4), 844–853. https://doi.org/10.1093/schbul/sbx140
Miller, Jacob A., Matthew A. Scult, Emily Drabant Conley, Qiang Chen, Daniel R. Weinberger, and Ahmad R. Hariri. “Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults.Schizophrenia Bulletin 44, no. 4 (June 2018): 844–53. https://doi.org/10.1093/schbul/sbx140.
Miller JA, Scult MA, Conley ED, Chen Q, Weinberger DR, Hariri AR. Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults. Schizophrenia bulletin. 2018 Jun;44(4):844–53.
Miller, Jacob A., et al. “Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults.Schizophrenia Bulletin, vol. 44, no. 4, June 2018, pp. 844–53. Epmc, doi:10.1093/schbul/sbx140.
Miller JA, Scult MA, Conley ED, Chen Q, Weinberger DR, Hariri AR. Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults. Schizophrenia bulletin. 2018 Jun;44(4):844–853.
Journal cover image

Published In

Schizophrenia bulletin

DOI

EISSN

1745-1701

ISSN

1787-9965

Publication Date

June 2018

Volume

44

Issue

4

Start / End Page

844 / 853

Related Subject Headings

  • Young Adult
  • Schizophrenia
  • Psychiatry
  • Prefrontal Cortex
  • Multifactorial Inheritance
  • Memory, Short-Term
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Genome-Wide Association Study