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Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength.

Publication ,  Journal Article
Racette, SB; Rochon, J; Uhrich, ML; Villareal, DT; DAS, SK; Fontana, L; Bhapkar, M; Martin, CK; Redman, LM; Fuss, PJ; Roberts, SB; Kraus, WE
Published in: Med Sci Sports Exerc
November 2017

PURPOSE: Calorie restriction (CR) improves health span and delays age-related diseases in many species. The multicenter Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) study was the first randomized controlled trial of CR in nonobese humans. The aim of this investigation was to determine the effects of CR on V˙O2max and muscle strength in the CALERIE trial. METHODS: Healthy, normal-weight, and mildly overweight women and men (n = 218, mean ± SE age = 37.9 ± 0.5 yr) were randomized to 25% CR or an ad libitum (AL) control condition in a 2:1 allocation (143 CR, 75 AL). V˙O2max was determined with an incremental treadmill test; the strength of the knee flexors and extensors was assessed by dynamometry at baseline, 1 yr, and 2 yr. RESULTS: The CR group achieved an average 11.9% ± 0.7% CR during the 2-yr intervention. Body weight decreased in CR (-7.7 ± 0.4 kg), but not AL (+0.2 ± 0.5 kg). Absolute V˙O2max (L·min) decreased at 1 and 2 yr with CR, whereas V˙O2max expressed relative to body mass increased at both time points (1 yr: +2.2 ± 0.4; 2 yr: +1.9 ± 0.5 mL·kg·min) and relative to AL. The CR group increased their treadmill test time and workload at 1 and 2 yr. Strength results in CR were similar, with decreases in absolute flexor and extensor strength, but increases when expressed relative to body mass. No changes were observed for V˙O2max expressed relative to lean body mass or leg lean mass. CONCLUSIONS: Two years of modest CR without a structured exercise component did not appear to compromise aerobic capacity in healthy nonobese adults. The clinical implications of the observed changes in V˙O2max and muscle strength will be important to explore in future studies.

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Published In

Med Sci Sports Exerc

DOI

EISSN

1530-0315

Publication Date

November 2017

Volume

49

Issue

11

Start / End Page

2240 / 2249

Location

United States

Related Subject Headings

  • Young Adult
  • Weight Loss
  • Sport Sciences
  • Physical Endurance
  • Oxygen Consumption
  • Overweight
  • Muscle Strength
  • Middle Aged
  • Male
  • Longitudinal Studies
 

Citation

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Racette, S. B., Rochon, J., Uhrich, M. L., Villareal, D. T., DAS, S. K., Fontana, L., … Kraus, W. E. (2017). Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength. Med Sci Sports Exerc, 49(11), 2240–2249. https://doi.org/10.1249/MSS.0000000000001353
Racette, Susan B., James Rochon, Mary L. Uhrich, Dennis T. Villareal, Sai Krupa DAS, Luigi Fontana, Manjushri Bhapkar, et al. “Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength.Med Sci Sports Exerc 49, no. 11 (November 2017): 2240–49. https://doi.org/10.1249/MSS.0000000000001353.
Racette SB, Rochon J, Uhrich ML, Villareal DT, DAS SK, Fontana L, et al. Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength. Med Sci Sports Exerc. 2017 Nov;49(11):2240–9.
Racette, Susan B., et al. “Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength.Med Sci Sports Exerc, vol. 49, no. 11, Nov. 2017, pp. 2240–49. Pubmed, doi:10.1249/MSS.0000000000001353.
Racette SB, Rochon J, Uhrich ML, Villareal DT, DAS SK, Fontana L, Bhapkar M, Martin CK, Redman LM, Fuss PJ, Roberts SB, Kraus WE. Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength. Med Sci Sports Exerc. 2017 Nov;49(11):2240–2249.

Published In

Med Sci Sports Exerc

DOI

EISSN

1530-0315

Publication Date

November 2017

Volume

49

Issue

11

Start / End Page

2240 / 2249

Location

United States

Related Subject Headings

  • Young Adult
  • Weight Loss
  • Sport Sciences
  • Physical Endurance
  • Oxygen Consumption
  • Overweight
  • Muscle Strength
  • Middle Aged
  • Male
  • Longitudinal Studies