Synthesis of N-Substituted Sulfamate Esters from Sulfamic Acid Salts by Activation with Triphenylphosphine Ditriflate.

Journal Article (Journal Article)

A general approach to access sulfamate esters through preparation of sulfamic acid salts, subsequent activation with triphenylphosphine ditriflate, and nucleophilic trapping is disclosed. The method proceeds in modest to excellent yields to incorporate nucleophiles derived from aliphatic alcohols and phenols. This approach can be employed to furnish differentially substituted sulfamides.

Full Text

Duke Authors

Cited Authors

  • Blackburn, JM; Short, MA; Castanheiro, T; Ayer, SK; Muellers, TD; Roizen, JL

Published Date

  • November 2017

Published In

Volume / Issue

  • 19 / 21

Start / End Page

  • 6012 - 6015

PubMed ID

  • 29048913

Pubmed Central ID

  • 29048913

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/acs.orglett.7b03059


  • eng