Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy.

Published online

Journal Article

Spinal and bulbar muscular atrophy (SBMA) is a progressive neuromuscular disease caused by polyglutamine expansion in the androgen receptor (AR) protein. Despite extensive research, the exact pathogenic mechanisms underlying SBMA remain elusive. In this study, we present evidence that Nemo-like kinase (NLK) promotes disease pathogenesis across multiple SBMA model systems. Most remarkably, loss of one copy of Nlk rescues SBMA phenotypes in mice, including extending lifespan. We also investigated the molecular mechanisms by which NLK exerts its effects in SBMA. Specifically, we have found that NLK can phosphorylate the mutant polyglutamine-expanded AR, enhance its aggregation, and promote AR-dependent gene transcription by regulating AR-cofactor interactions. Furthermore, NLK modulates the toxicity of a mutant AR fragment via a mechanism that is independent of AR-mediated gene transcription. Our findings uncover a crucial role for NLK in controlling SBMA toxicity and reveal a novel avenue for therapy development in SBMA.

Full Text

Duke Authors

Cited Authors

  • Todd, TW; Kokubu, H; Miranda, HC; Cortes, CJ; La Spada, AR; Lim, J

Published Date

  • August 26, 2015

Published In

Volume / Issue

  • 4 /

Start / End Page

  • e08493 -

PubMed ID

  • 26308581

Pubmed Central ID

  • 26308581

Electronic International Standard Serial Number (EISSN)

  • 2050-084X

Digital Object Identifier (DOI)

  • 10.7554/eLife.08493

Language

  • eng

Conference Location

  • England