Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells.


Journal Article

Neuroblastoma (NB) is the most common solid extracranial tumor in children. Here we showed that trichostatin A, a histone deacetylase inhibitor (HDACi), decreases cell viability in three NB cell lines of different phenotypes. The treatment leads to G2/M-phase arrest, apoptosis and autophagy. Autophagy induction accompanies apoptosis in the most proliferative, N-Myc overexpressing cells. In contrast, autophagy precedes apoptosis and acts as a protective mechanism in the less proliferative, non-N-Myc overexpressing cells. Therefore, the autophagy induction is a relevant event in the NB response to HDACis, and it should be considered in the design of new treatments for this malignancy.

Full Text

Cited Authors

  • Francisco, R; Pérez-Perarnau, A; Cortés, C; Gil, J; Tauler, A; Ambrosio, S

Published Date

  • May 2012

Published In

Volume / Issue

  • 318 / 1

Start / End Page

  • 42 - 52

PubMed ID

  • 22186300

Pubmed Central ID

  • 22186300

Electronic International Standard Serial Number (EISSN)

  • 1872-7980

International Standard Serial Number (ISSN)

  • 0304-3835

Digital Object Identifier (DOI)

  • 10.1016/j.canlet.2011.11.036


  • eng