Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells.

Published

Journal Article

Neuroblastoma (NB) is the most common solid extracranial tumor in children. Here we showed that trichostatin A, a histone deacetylase inhibitor (HDACi), decreases cell viability in three NB cell lines of different phenotypes. The treatment leads to G2/M-phase arrest, apoptosis and autophagy. Autophagy induction accompanies apoptosis in the most proliferative, N-Myc overexpressing cells. In contrast, autophagy precedes apoptosis and acts as a protective mechanism in the less proliferative, non-N-Myc overexpressing cells. Therefore, the autophagy induction is a relevant event in the NB response to HDACis, and it should be considered in the design of new treatments for this malignancy.

Full Text

Cited Authors

  • Francisco, R; Pérez-Perarnau, A; Cortés, C; Gil, J; Tauler, A; Ambrosio, S

Published Date

  • May 2012

Published In

Volume / Issue

  • 318 / 1

Start / End Page

  • 42 - 52

PubMed ID

  • 22186300

Pubmed Central ID

  • 22186300

Electronic International Standard Serial Number (EISSN)

  • 1872-7980

International Standard Serial Number (ISSN)

  • 0304-3835

Digital Object Identifier (DOI)

  • 10.1016/j.canlet.2011.11.036

Language

  • eng