The impact of cellular metabolism on chromatin dynamics and epigenetics.

Journal Article (Journal Article;Review)

The substrates used to modify nucleic acids and chromatin are affected by nutrient availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a fundamental component of chromatin status and thereby of genome regulation. Here we describe the biochemical and genetic principles of how metabolism can influence chromatin biology and epigenetics, discuss the functional roles of this interplay in developmental and cancer biology, and present future directions in this rapidly emerging area.

Full Text

Duke Authors

Cited Authors

  • Reid, MA; Dai, Z; Locasale, JW

Published Date

  • November 2017

Published In

Volume / Issue

  • 19 / 11

Start / End Page

  • 1298 - 1306

PubMed ID

  • 29058720

Pubmed Central ID

  • PMC5886854

Electronic International Standard Serial Number (EISSN)

  • 1476-4679

Digital Object Identifier (DOI)

  • 10.1038/ncb3629


  • eng

Conference Location

  • England