Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity.

Journal Article (Journal Article)

Six previously undescribed diterpenoids, named euphorantins S-T and euphorneroids A-D, including ingol and ent-atisane types, along with eleven known diterpenoids, were isolated from Euphorbia neriifolia. Their structures were elucidated on the basis of extensive NMR analysis and high resolution mass spectrometry. Euphorneroid D and ent-3-oxoatisan-16α,17-acetonide exhibited moderate anti-HIV-1 activities, with EC50 values of 34 μM (SI = 2.3) and 24 μM (SI = 1.9), respectively.

Full Text

Duke Authors

Cited Authors

  • Yan, S-L; Li, Y-H; Chen, X-Q; Liu, D; Chen, C-H; Li, R-T

Published Date

  • January 2018

Published In

Volume / Issue

  • 145 /

Start / End Page

  • 40 - 47

PubMed ID

  • 29080411

Pubmed Central ID

  • 29080411

Electronic International Standard Serial Number (EISSN)

  • 1873-3700

Digital Object Identifier (DOI)

  • 10.1016/j.phytochem.2017.10.006


  • eng

Conference Location

  • England