Are Well-Informed Potential Trial Participants More Likely to Participate?

Journal Article (Journal Article)

Bearing in mind the importance of the informed consent, flaws in this process may be a barrier to participants' recruitment. Our objective was to determine the relationship between the degree of comprehension of the informed consent document plus the importance given to individual elements by potential participants of a hypothetical trial and their willingness to participate in such trials. We performed an Online Survey simulating an emergency department trial recruitment, posteriorly evaluating participants' ratings of importance and self-assessed comprehension of specific topics of the informed consent document. Only 10% of the sample read the entire document. Some specific topics were associated with willingness to participate in the hypothetical trial, but simple composite additive scores of comprehension and importance were not. We concluded that participants in general do not read the entire informed consent document and that importance given to specific topics may influence willingness to participate.

Full Text

Duke Authors

Cited Authors

  • de Oliveira, LLH; Vissoci, JRN; Machado, WDL; Rodrigues, CG; Limkakeng, AT

Published Date

  • December 2017

Published In

Volume / Issue

  • 12 / 5

Start / End Page

  • 363 - 371

PubMed ID

  • 29073806

Electronic International Standard Serial Number (EISSN)

  • 1556-2654

Digital Object Identifier (DOI)

  • 10.1177/1556264617737163


  • eng

Conference Location

  • United States