Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain.

Journal Article (Journal Article)

Calcineurin has been implicated as part of a critical signaling pathway for learning and memory, and recent data suggest that calcineurin activation mediates some of the neurotoxicity of the Alzheimer related neurotoxin Aβ. Immunosuppression via calcineurin inhibition with the compound FK506 is an important treatment for organ transplant patients. Here we use Golgi impregnation techniques, along with a new survival analysis-based statistical approach for analysis of dendritic complexity, to show that in healthy adult mice one week of treatment with FK506 affects both the branching patterns and dendritic spine density of cortical neurons. These results indicate that calcineurin inhibition leads to readily detectable changes in brain morphology, further implicating calcineurin related pathways in both the function and structure of the adult brain.

Full Text

Duke Authors

Cited Authors

  • Spires-Jones, TL; Kay, K; Matsouka, R; Rozkalne, A; Betensky, RA; Hyman, BT

Published Date

  • January 10, 2011

Published In

Volume / Issue

  • 487 / 3

Start / End Page

  • 260 - 263

PubMed ID

  • 20970476

Pubmed Central ID

  • PMC3010509

Electronic International Standard Serial Number (EISSN)

  • 1872-7972

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2010.10.033


  • eng

Conference Location

  • Ireland