Return of widespread chloroquine-sensitive Plasmodium falciparum to Malawi.


Journal Article

BACKGROUND: The return of chloroquine-sensitive Plasmodium falciparum to the limited area of Blantyre, Malawi, has been well demonstrated in several studies. METHODS: To characterize chloroquine susceptibility over a wide geographic area, infants and children aged 6-59 months were selected using 2-stage cluster sampling in 8 Malawian districts. Pyrosequencing of the pfcrt gene codon 76 region was performed for children with asexual parasitemia. RESULTS: Of 7145 children, 1150 had microscopic asexual parasitemia, and sequencing was performed in 685, of whom 1 had a chloroquine-resistant genotype. CONCLUSIONS: Systematic countrywide sampling demonstrates that the chloroquine pfcrt genotype has reached near-fixation, raising the possibility of reintroducing chloroquine for malaria prevention and treatment.

Full Text

Duke Authors

Cited Authors

  • Frosch, AEP; Laufer, MK; Mathanga, DP; Takala-Harrison, S; Skarbinski, J; Claassen, CW; Dzinjalamala, FK; Plowe, CV

Published Date

  • October 1, 2014

Published In

Volume / Issue

  • 210 / 7

Start / End Page

  • 1110 - 1114

PubMed ID

  • 24723474

Pubmed Central ID

  • 24723474

Electronic International Standard Serial Number (EISSN)

  • 1537-6613

Digital Object Identifier (DOI)

  • 10.1093/infdis/jiu216


  • eng

Conference Location

  • United States