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No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali.

Publication ,  Journal Article
Maiga, AW; Fofana, B; Sagara, I; Dembele, D; Dara, A; Traore, OB; Toure, S; Sanogo, K; Dama, S; Sidibe, B; Kone, A; Thera, MA; Plowe, CV ...
Published in: The American journal of tropical medicine and hygiene
July 2012

Plasmodium falciparum resistance to artemisinins by delayed parasite clearance is present in Southeast Asia. Scant data on parasite clearance after artemisinins are available from Africa, where transmission is high, burden is greatest, and artemisinin use is being scaled up. Children 1-10 years of age with uncomplicated malaria were treated with 7 days of artesunate and followed for 28 days. Blood smears were done every 8 hours until negative by light microscopy. Results were compared with a similar study conducted in the same village in 2002-2004. The polymerase chain reaction-corrected cure rate was 100%, identical to 2002-2004. By 24 hours after treatment initiation, 37.0% of participants had cleared parasitemia, compared with 31.9% in 2002-2004 (P = 0.5). The median parasite clearance time was 32 hours. Only one participant still had parasites at 48 hours and no participant presented parasitemia at 72 hours. Artesunate was highly efficacious, with no evidence of delayed parasite clearance. We provide baseline surveillance data for the emergence or dissemination of P. falciparum resistance in sub-Saharan Africa.

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Published In

The American journal of tropical medicine and hygiene

DOI

EISSN

1476-1645

ISSN

0002-9637

Publication Date

July 2012

Volume

87

Issue

1

Start / End Page

23 / 28

Related Subject Headings

  • Tropical Medicine
  • Parasitemia
  • Mali
  • Male
  • Malaria, Falciparum
  • Infant
  • Humans
  • Female
  • Child, Preschool
  • Child
 

Citation

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ICMJE
MLA
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Maiga, A. W., Fofana, B., Sagara, I., Dembele, D., Dara, A., Traore, O. B., … Djimde, A. A. (2012). No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali. The American Journal of Tropical Medicine and Hygiene, 87(1), 23–28. https://doi.org/10.4269/ajtmh.2012.12-0058
Maiga, Amelia W., Bakary Fofana, Issaka Sagara, Demba Dembele, Antoine Dara, Oumar Bila Traore, Sekou Toure, et al. “No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali.The American Journal of Tropical Medicine and Hygiene 87, no. 1 (July 2012): 23–28. https://doi.org/10.4269/ajtmh.2012.12-0058.
Maiga AW, Fofana B, Sagara I, Dembele D, Dara A, Traore OB, et al. No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali. The American journal of tropical medicine and hygiene. 2012 Jul;87(1):23–8.
Maiga, Amelia W., et al. “No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali.The American Journal of Tropical Medicine and Hygiene, vol. 87, no. 1, July 2012, pp. 23–28. Epmc, doi:10.4269/ajtmh.2012.12-0058.
Maiga AW, Fofana B, Sagara I, Dembele D, Dara A, Traore OB, Toure S, Sanogo K, Dama S, Sidibe B, Kone A, Thera MA, Plowe CV, Doumbo OK, Djimde AA. No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali. The American journal of tropical medicine and hygiene. 2012 Jul;87(1):23–28.

Published In

The American journal of tropical medicine and hygiene

DOI

EISSN

1476-1645

ISSN

0002-9637

Publication Date

July 2012

Volume

87

Issue

1

Start / End Page

23 / 28

Related Subject Headings

  • Tropical Medicine
  • Parasitemia
  • Mali
  • Male
  • Malaria, Falciparum
  • Infant
  • Humans
  • Female
  • Child, Preschool
  • Child