Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America.


Journal Article

Multidrug resistance is a major obstacle to the control of Plasmodium falciparum malaria, and its origins and modes of dissemination are imperfectly understood. In this study, haplotyping and microsatellite analysis of malaria from 5 regions of the South American Amazon support the conclusion that the parasite mutations conferring mid- and high-level resistance to the antifolate combination sulfadoxine-pyrimethamine have a common origin. Parasites harboring these mutations are also found to share drug-resistance alleles that confer a unique chloroquine resistance phenotype and to be similar at loci not linked to drug resistance, although not genetically identical. Since the 1980s, multidrug-resistant P. falciparum has spread in a north-northwest manner across the continent, from an origin likely in the lower Amazon. This study highlights the importance of continent-wide malaria-control policies and suggests that the containment of resistance to the next generation of therapies may be feasible.

Full Text

Duke Authors

Cited Authors

  • Cortese, JF; Caraballo, A; Contreras, CE; Plowe, CV

Published Date

  • October 1, 2002

Published In

Volume / Issue

  • 186 / 7

Start / End Page

  • 999 - 1006

PubMed ID

  • 12232841

Pubmed Central ID

  • 12232841

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/342946


  • eng

Conference Location

  • United States