Association of Schistosoma haematobium infection with protection against acute Plasmodium falciparum malaria in Malian children.

Published

Journal Article

Plasmodium falciparum and Schistosoma haematobium are co-endemic parasitic diseases with worldwide distribution. Evidence suggests interactions occur between helminthic and malaria infections, although it is unclear whether this effect is beneficial or harmful to the host. Malian children 4-14 years of age with asymptomatic S. haematobium infection (SP) (n = 338) were prospectively matched by age, sex, and residence to children without schistosomiasis (SN) (n = 338) who were cleared of occult intestinal parasites, and followed-up for one malaria transmission season (25 weeks). The time to the first clinical malaria infection, incidence of malaria episodes, and parasitemia were recorded. Age associated protection from malaria in children with schistosomiasis was observed. SP children (4-8 years of age) compared with SN children demonstrated delayed time to first clinical malaria infection (74 versus 59 days; P = 0.04), fewer numbers of malaria episodes (1.55 versus 1.81 infections; P = 0.03) and lower geometric mean parasite densities (6,359 versus 9,874 asexual forms/mm(3); P = 0.07) at first infection. No association between schistosomiasis and P. falciparum malaria was observed in children 9-14 years of age. We conclude that underlying schistosomiasis is associated with protection against clinical falciparum malaria in an age-dependent manner.

Full Text

Duke Authors

Cited Authors

  • Lyke, KE; Dicko, A; Dabo, A; Sangare, L; Kone, A; Coulibaly, D; Guindo, A; Traore, K; Daou, M; Diarra, I; Sztein, MB; Plowe, CV; Doumbo, OK

Published Date

  • December 2005

Published In

Volume / Issue

  • 73 / 6

Start / End Page

  • 1124 - 1130

PubMed ID

  • 16354824

Pubmed Central ID

  • 16354824

Electronic International Standard Serial Number (EISSN)

  • 1476-1645

International Standard Serial Number (ISSN)

  • 0002-9637

Digital Object Identifier (DOI)

  • 10.4269/ajtmh.2005.73.1124

Language

  • eng