Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S.

Published

Journal Article

The malaria hypothesis proposes a survival advantage for individuals with hemoglobin variants in areas of endemic Plasmodium falciparum malaria. Hemoglobin C (HbC) is a possible example in West Africa, where this hemoglobin has a centric distribution with high frequencies among certain populations including the Dogon ethnic group. To test whether HbC is associated with protection from malaria, we performed a case-control study in the Dogon of Bandiagara, Mali. HbC was present in 68 of 391 (17.4%) of uncomplicated malaria control cases, whereas it was detected in only 3 of 67 cases (4.5%) of severe malaria (odds ratio [OR], 0.22; P =. 01). Further, HbC was present in only 1 of 34 cases (2.9%) with cerebral manifestations, the most common presentation of severe malaria in this population (OR, 0.14; P =.03). Episodes of uncomplicated malaria and parasitemias (4800-205 050/microL) were identified in cases of homozygous HbC (HbCC), which indicates that P falciparum parasites are able to efficiently replicate within HbCC erythrocytes in vivo. These findings suggest that HbC does not protect against infection or uncomplicated malaria but can protect against severe malaria in the Dogon population of Bandiagara, Mali. The data also suggest that the protective effect associated with HbC may be greater than that of HbS in this population.

Full Text

Duke Authors

Cited Authors

  • Agarwal, A; Guindo, A; Cissoko, Y; Taylor, JG; Coulibaly, D; Koné, A; Kayentao, K; Djimde, A; Plowe, CV; Doumbo, O; Wellems, TE; Diallo, D

Published Date

  • October 1, 2000

Published In

Volume / Issue

  • 96 / 7

Start / End Page

  • 2358 - 2363

PubMed ID

  • 11001883

Pubmed Central ID

  • 11001883

International Standard Serial Number (ISSN)

  • 0006-4971

Language

  • eng

Conference Location

  • United States