Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum.


Journal Article (Review)

Chloroquine resistance in Plasmodium falciparum has recently been shown to result from mutations in the novel vacuolar transporter, PfCRT. Field studies have demonstrated the importance of these mutations in clinical resistance. Although a pfcrt ortholog has been identified in Plasmodiumvivax, there is no association between in vivo chloroquine resistance and codon mutations in the P. vivax gene. This is consistent with lines of evidence that suggest alternative mechanisms of chloroquine resistance among various malaria parasite species.

Full Text

Duke Authors

Cited Authors

  • Carlton, JM; Fidock, DA; Djimdé, A; Plowe, CV; Wellems, TE

Published Date

  • August 2001

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 415 - 420

PubMed ID

  • 11495804

Pubmed Central ID

  • 11495804

International Standard Serial Number (ISSN)

  • 1369-5274

Digital Object Identifier (DOI)

  • 10.1016/s1369-5274(00)00228-9


  • eng

Conference Location

  • England