The evolution of drug-resistant malaria.


Journal Article

Molecular epidemiological investigations have uncovered the patterns of emergence and global spread of Plasmodium falciparum resistance to chloroquine and sulfadoxine-pyrimethamine. Malaria parasites highly resistant to chloroquine and pyrimethamine spread from Asian origins to Africa, at great cost to human health and life. If artemisinin-resistant falciparum malaria follows the same pattern, renewed efforts to eliminate and eradicate malaria will be gravely threatened. This paper, adapted from a talk given in honour of Professor Malcolm Molyneux in Liverpool in September 2008, reviews the rise and fall of clinically important forms of drug-resistant falciparum malaria and considers how lessons learned from studying the evolution of drug-resistant malaria can be applied to efforts to prevent and deter resistance.

Full Text

Cited Authors

  • Plowe, CV

Published Date

  • April 2009

Published In

Volume / Issue

  • 103 Suppl 1 /

Start / End Page

  • S11 - S14

PubMed ID

  • 19084883

Pubmed Central ID

  • 19084883

Electronic International Standard Serial Number (EISSN)

  • 1878-3503

International Standard Serial Number (ISSN)

  • 0035-9203

Digital Object Identifier (DOI)

  • 10.1016/j.trstmh.2008.11.002


  • eng