Platelet-mediated clumping of Plasmodium falciparum infected erythrocytes is associated with high parasitemia but not severe clinical manifestations of malaria in African children.


Journal Article

Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is an adhesive phenotype commonly found in field isolates that has previously been associated with severe malaria. Here, clumping was assessed in 131 isolates from Malian children. The clumping phenotype was seen in 6% (N = 51) of uncomplicated malaria, 24% (N = 51) of severe malaria, and 45% (N = 29) of high parasitemia non-severe malaria isolates. Multivariate analysis indicated that clumping was strongly positively associated with parasitemia (F(1,122) = 24.1, P < 0.001) but not with disease category (F(2,122) = 1.8, P = 0.17). Therefore platelet-mediated clumping in Malian P. falciparum isolates is primarily associated with high parasitemia and not with severe clinical manifestations of malaria.

Full Text

Duke Authors

Cited Authors

  • Arman, M; Raza, A; Tempest, LJ; Lyke, KE; Thera, MA; Koné, A; Plowe, CV; Doumbo, OK; Rowe, JA

Published Date

  • November 2007

Published In

Volume / Issue

  • 77 / 5

Start / End Page

  • 943 - 946

PubMed ID

  • 17984358

Pubmed Central ID

  • 17984358

Electronic International Standard Serial Number (EISSN)

  • 1476-1645


  • eng

Conference Location

  • United States