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Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.

Publication ,  Journal Article
Lu, X; Peloso, GM; Liu, DJ; Wu, Y; Zhang, H; Zhou, W; Li, J; Tang, CS-M; Dorajoo, R; Li, H; Long, J; Guo, X; Xu, M; Spracklen, CN; Chen, Y ...
Published in: Nat Genet
December 2017

Most genome-wide association studies have been of European individuals, even though most genetic variation in humans is seen only in non-European samples. To search for novel loci associated with blood lipid levels and clarify the mechanism of action at previously identified lipid loci, we used an exome array to examine protein-coding genetic variants in 47,532 East Asian individuals. We identified 255 variants at 41 loci that reached chip-wide significance, including 3 novel loci and 14 East Asian-specific coding variant associations. After a meta-analysis including >300,000 European samples, we identified an additional nine novel loci. Sixteen genes were identified by protein-altering variants in both East Asians and Europeans, and thus are likely to be functional genes. Our data demonstrate that most of the low-frequency or rare coding variants associated with lipids are population specific, and that examining genomic data across diverse ancestries may facilitate the identification of functional genes at associated loci.

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

December 2017

Volume

49

Issue

12

Start / End Page

1722 / 1730

Location

United States

Related Subject Headings

  • White People
  • Lipids
  • Lipid Metabolism
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Variation
  • Genetic Predisposition to Disease
  • Gene Frequency
  • Exome
 

Citation

APA
Chicago
ICMJE
MLA
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Lu, X., Peloso, G. M., Liu, D. J., Wu, Y., Zhang, H., Zhou, W., … Willer, C. J. (2017). Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. Nat Genet, 49(12), 1722–1730. https://doi.org/10.1038/ng.3978
Lu, Xiangfeng, Gina M. Peloso, Dajiang J. Liu, Ying Wu, He Zhang, Wei Zhou, Jun Li, et al. “Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.Nat Genet 49, no. 12 (December 2017): 1722–30. https://doi.org/10.1038/ng.3978.
Lu, Xiangfeng, et al. “Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.Nat Genet, vol. 49, no. 12, Dec. 2017, pp. 1722–30. Pubmed, doi:10.1038/ng.3978.
Lu X, Peloso GM, Liu DJ, Wu Y, Zhang H, Zhou W, Li J, Tang CS-M, Dorajoo R, Li H, Long J, Guo X, Xu M, Spracklen CN, Chen Y, Liu X, Zhang Y, Khor CC, Liu J, Sun L, Wang L, Gao Y-T, Hu Y, Yu K, Wang Y, Cheung CYY, Wang F, Huang J, Fan Q, Cai Q, Chen S, Shi J, Yang X, Zhao W, Sheu WH-H, Cherny SS, He M, Feranil AB, Adair LS, Gordon-Larsen P, Du S, Varma R, Chen Y-DI, Shu X-O, Lam KSL, Wong TY, Ganesh SK, Mo Z, Hveem K, Fritsche LG, Nielsen JB, Tse H-F, Huo Y, Cheng C-Y, Chen YE, Zheng W, Tai ES, Gao W, Lin X, Huang W, Abecasis G, GLGC Consortium, Kathiresan S, Mohlke KL, Wu T, Sham PC, Gu D, Willer CJ. Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. Nat Genet. 2017 Dec;49(12):1722–1730.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

December 2017

Volume

49

Issue

12

Start / End Page

1722 / 1730

Location

United States

Related Subject Headings

  • White People
  • Lipids
  • Lipid Metabolism
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Variation
  • Genetic Predisposition to Disease
  • Gene Frequency
  • Exome