A bioactive titanium foam scaffold for bone repair.


Journal Article

While titanium has been clinically successful as an orthopedic or dental implant material, performance problems still persist related to implant-bone interfacial strength and mechanical modulus mismatch between titanium and tissue. We describe here the preparation of a titanium foam as a better mechanical match to tissue with surfaces attractive to bone cells through deposition of an organically-modified apatite layer (organoapatite). In a rotating bioreactor, these organoapatite-coated foams are successfully colonized by preosteoblastic cells. Finite element analyses suggest that ingrown tissue in these systems may improve both implant performance and tissue formation through load-sharing and stress distribution. The novel metal-ceramic-polymer hybrid materials described here hold great promise for bone tissue engineering.

Full Text

Duke Authors

Cited Authors

  • Spoerke, ED; Murray, NG; Li, H; Brinson, LC; Dunand, DC; Stupp, SI

Published Date

  • September 2005

Published In

Volume / Issue

  • 1 / 5

Start / End Page

  • 523 - 533

PubMed ID

  • 16701832

Pubmed Central ID

  • 16701832

Electronic International Standard Serial Number (EISSN)

  • 1878-7568

International Standard Serial Number (ISSN)

  • 1742-7061

Digital Object Identifier (DOI)

  • 10.1016/j.actbio.2005.04.005


  • eng