Antenatal Bartter's syndrome: why is this not a lethal condition?

Published

Journal Article

There are four themes in this teaching exercise for Professor McCance. The first challenge was to explain how a premature infant with Bartter's syndrome could survive despite having such a severe degree of renal salt wasting. Second, the medical team wanted to know why there was such a dramatic decrease in the natriuresis in response to therapy, despite the presence of a permanent molecular defect that affected the loop of Henle. Third, Professor McCance was asked why this patient seemed to have a second rare disease, AQP2 deficiency type of nephrogenic diabetes insipidus. The fourth challenge was to develop a diagnostic test to help the parents of this baby titrate the dose of indomethacin to ensure an effective dose while minimizing the likelihood of developing nephrotoxicity. The missing links in this interesting story emerge during a discussion between the medical team and its mentor.

Full Text

Duke Authors

Cited Authors

  • Bockenhauer, D; Cruwys, M; Kleta, R; Halperin, LF; Wildgoose, P; Souma, T; Nukiwa, N; Cheema-Dhadli, S; Chong, CK; Kamel, KS; Davids, MR; Halperin, ML

Published Date

  • December 2008

Published In

Volume / Issue

  • 101 / 12

Start / End Page

  • 927 - 942

PubMed ID

  • 18829713

Pubmed Central ID

  • 18829713

Electronic International Standard Serial Number (EISSN)

  • 1460-2393

Digital Object Identifier (DOI)

  • 10.1093/qjmed/hcn119

Language

  • eng

Conference Location

  • England