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Antenatal Bartter's syndrome: why is this not a lethal condition?

Publication ,  Journal Article
Bockenhauer, D; Cruwys, M; Kleta, R; Halperin, LF; Wildgoose, P; Souma, T; Nukiwa, N; Cheema-Dhadli, S; Chong, CK; Kamel, KS; Davids, MR; Halperin, ML
Published in: QJM
December 2008

There are four themes in this teaching exercise for Professor McCance. The first challenge was to explain how a premature infant with Bartter's syndrome could survive despite having such a severe degree of renal salt wasting. Second, the medical team wanted to know why there was such a dramatic decrease in the natriuresis in response to therapy, despite the presence of a permanent molecular defect that affected the loop of Henle. Third, Professor McCance was asked why this patient seemed to have a second rare disease, AQP2 deficiency type of nephrogenic diabetes insipidus. The fourth challenge was to develop a diagnostic test to help the parents of this baby titrate the dose of indomethacin to ensure an effective dose while minimizing the likelihood of developing nephrotoxicity. The missing links in this interesting story emerge during a discussion between the medical team and its mentor.

Duke Scholars

Published In

QJM

DOI

EISSN

1460-2393

Publication Date

December 2008

Volume

101

Issue

12

Start / End Page

927 / 942

Location

England

Related Subject Headings

  • Sodium
  • Rats
  • Male
  • Loop of Henle
  • Kidney Diseases
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Indomethacin
  • Hyperaldosteronism
 

Citation

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Chicago
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Bockenhauer, D., Cruwys, M., Kleta, R., Halperin, L. F., Wildgoose, P., Souma, T., … Halperin, M. L. (2008). Antenatal Bartter's syndrome: why is this not a lethal condition? QJM, 101(12), 927–942. https://doi.org/10.1093/qjmed/hcn119
Bockenhauer, D., M. Cruwys, R. Kleta, L. F. Halperin, P. Wildgoose, T. Souma, N. Nukiwa, et al. “Antenatal Bartter's syndrome: why is this not a lethal condition?QJM 101, no. 12 (December 2008): 927–42. https://doi.org/10.1093/qjmed/hcn119.
Bockenhauer D, Cruwys M, Kleta R, Halperin LF, Wildgoose P, Souma T, et al. Antenatal Bartter's syndrome: why is this not a lethal condition? QJM. 2008 Dec;101(12):927–42.
Bockenhauer, D., et al. “Antenatal Bartter's syndrome: why is this not a lethal condition?QJM, vol. 101, no. 12, Dec. 2008, pp. 927–42. Pubmed, doi:10.1093/qjmed/hcn119.
Bockenhauer D, Cruwys M, Kleta R, Halperin LF, Wildgoose P, Souma T, Nukiwa N, Cheema-Dhadli S, Chong CK, Kamel KS, Davids MR, Halperin ML. Antenatal Bartter's syndrome: why is this not a lethal condition? QJM. 2008 Dec;101(12):927–942.
Journal cover image

Published In

QJM

DOI

EISSN

1460-2393

Publication Date

December 2008

Volume

101

Issue

12

Start / End Page

927 / 942

Location

England

Related Subject Headings

  • Sodium
  • Rats
  • Male
  • Loop of Henle
  • Kidney Diseases
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Indomethacin
  • Hyperaldosteronism