S-100β and Antioxidant Capacity in Cerebrospinal Fluid during and after Thoracic Endovascular Aortic Repair.

Journal Article (Journal Article)

BACKGROUND: Thoracic Endovascular Aortic Repair (TEVAR) has substantially decreased the mortality and major complications from aortic surgery. However, neurological complications such as spinal cord ischemia may still occur after TEVAR. S-100β is a biomarker of central nervous system injury, and oxidant injury plays an important role in neurological injury. In this pilot study, we examined the trends of S-100β and antioxidant capacity in the CSF during and after TEVAR. METHODS: We recruited 10 patients who underwent elective TEVAR. CSF samples were collected through a lumbar catheter at the following time points: before the start of surgery (T0) and immediately (T1) and 24 (T2) and 48 hours (T3) after the deployment of the aortic stent. S-100β and CSF antioxidant capacity were analyzed with the use of commercially available kits. RESULTS: We observed that the level of S-100β in all of the subjects at 24 hours after the deployment of the aortic stent (T2) increased. However, the levels of S-100β at T1 and T3 were comparable to the baseline value. The antioxidant capacity remained unchanged. No patient had a clinical neurologic complication. CONCLUSIONS: Our observations may indicate biochemical/subclinical central nervous system injury attributable to the deployment of the aortic stent.

Full Text

Duke Authors

Cited Authors

  • Nandate, K; Sharma, D; Olivar, H; Hallman, M; Ramaiah, R; Joffe, A; Roche, A; Krishnamoorthy, V

Published Date

  • 2017

Published In

Volume / Issue

  • 2017 /

Start / End Page

  • 6875195 -

PubMed ID

  • 28740858

Pubmed Central ID

  • PMC5504939

International Standard Serial Number (ISSN)

  • 2356-7872

Digital Object Identifier (DOI)

  • 10.1155/2017/6875195


  • eng

Conference Location

  • United States