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Cardiac Dysfunction After Neurologic Injury: What Do We Know and Where Are We Going?

Publication ,  Journal Article
Krishnamoorthy, V; Mackensen, GB; Gibbons, EF; Vavilala, MS
Published in: Chest
May 2016

Recent literature has implicated severe neurologic injuries, such as aneurysmal subarachnoid hemorrhage, as a cause of cardiac dysfunction, impaired hemodynamic function, and poor outcomes. Mechanistic links between the brain and the heart have been explored in detail over the past several decades, and catecholamine excess, neuroendocrine dysfunction, and unchecked inflammation all likely contribute to the pathophysiologic process. Although cardiac dysfunction has also been described in other disease paradigms, including septic shock and thermal injury, there is likely a common underlying pathophysiology. In this review, we will examine the pathophysiology of cardiac dysfunction after neurologic injury, discuss the evidence surrounding cardiac dysfunction after different neurologic injuries, and suggest future research goals to gain knowledge and improve outcomes in this patient population.

Duke Scholars

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Published In

Chest

DOI

EISSN

1931-3543

Publication Date

May 2016

Volume

149

Issue

5

Start / End Page

1325 / 1331

Location

United States

Related Subject Headings

  • Takotsubo Cardiomyopathy
  • Subarachnoid Hemorrhage
  • Stroke
  • Respiratory System
  • Nervous System Diseases
  • Myocardial Stunning
  • Humans
  • Heart Diseases
  • Epilepsy
  • Central Nervous System Infections
 

Citation

APA
Chicago
ICMJE
MLA
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Krishnamoorthy, V., Mackensen, G. B., Gibbons, E. F., & Vavilala, M. S. (2016). Cardiac Dysfunction After Neurologic Injury: What Do We Know and Where Are We Going? Chest, 149(5), 1325–1331. https://doi.org/10.1016/j.chest.2015.12.014
Krishnamoorthy, Vijay, G Burkhard Mackensen, Edward F. Gibbons, and Monica S. Vavilala. “Cardiac Dysfunction After Neurologic Injury: What Do We Know and Where Are We Going?Chest 149, no. 5 (May 2016): 1325–31. https://doi.org/10.1016/j.chest.2015.12.014.
Krishnamoorthy V, Mackensen GB, Gibbons EF, Vavilala MS. Cardiac Dysfunction After Neurologic Injury: What Do We Know and Where Are We Going? Chest. 2016 May;149(5):1325–31.
Krishnamoorthy, Vijay, et al. “Cardiac Dysfunction After Neurologic Injury: What Do We Know and Where Are We Going?Chest, vol. 149, no. 5, May 2016, pp. 1325–31. Pubmed, doi:10.1016/j.chest.2015.12.014.
Krishnamoorthy V, Mackensen GB, Gibbons EF, Vavilala MS. Cardiac Dysfunction After Neurologic Injury: What Do We Know and Where Are We Going? Chest. 2016 May;149(5):1325–1331.

Published In

Chest

DOI

EISSN

1931-3543

Publication Date

May 2016

Volume

149

Issue

5

Start / End Page

1325 / 1331

Location

United States

Related Subject Headings

  • Takotsubo Cardiomyopathy
  • Subarachnoid Hemorrhage
  • Stroke
  • Respiratory System
  • Nervous System Diseases
  • Myocardial Stunning
  • Humans
  • Heart Diseases
  • Epilepsy
  • Central Nervous System Infections