Cardiac Dysfunction After Neurologic Injury: What Do We Know and Where Are We Going?

Journal Article (Journal Article;Review)

Recent literature has implicated severe neurologic injuries, such as aneurysmal subarachnoid hemorrhage, as a cause of cardiac dysfunction, impaired hemodynamic function, and poor outcomes. Mechanistic links between the brain and the heart have been explored in detail over the past several decades, and catecholamine excess, neuroendocrine dysfunction, and unchecked inflammation all likely contribute to the pathophysiologic process. Although cardiac dysfunction has also been described in other disease paradigms, including septic shock and thermal injury, there is likely a common underlying pathophysiology. In this review, we will examine the pathophysiology of cardiac dysfunction after neurologic injury, discuss the evidence surrounding cardiac dysfunction after different neurologic injuries, and suggest future research goals to gain knowledge and improve outcomes in this patient population.

Full Text

Duke Authors

Cited Authors

  • Krishnamoorthy, V; Mackensen, GB; Gibbons, EF; Vavilala, MS

Published Date

  • May 2016

Published In

Volume / Issue

  • 149 / 5

Start / End Page

  • 1325 - 1331

PubMed ID

  • 26836901

Pubmed Central ID

  • PMC4944787

Electronic International Standard Serial Number (EISSN)

  • 1931-3543

Digital Object Identifier (DOI)

  • 10.1016/j.chest.2015.12.014


  • eng

Conference Location

  • United States