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Temporal Changes in Left Ventricular Systolic Function and Use of Echocardiography in Adult Heart Donors.

Publication ,  Journal Article
Borbely, XI; Krishnamoorthy, V; Modi, S; Rowhani-Rahbar, A; Gibbons, E; Souter, MJ; Vavilala, MS
Published in: Neurocrit Care
August 2015

BACKGROUND: One reason for refusal of donor hearts is the development of left ventricular systolic dysfunction, a condition reported to occur in up to 42 % of adults with brain death. Prior studies have suggested that appropriate donor management and evaluation of cardiac dysfunction with serial echocardiography (TTE) can improve organ procurement. The aims of our study are to examine the prevalence and describe longitudinal changes in cardiac dysfunction after brain death. METHODS: A cross-sectional study was performed using the Life Center Northwest organ database to identify potential adult heart donors diagnosed with brain death between January 2011 and November 2013. 246 potential donors with at least one TTE following brain death were identified. 58 donors received serial TTEs. Echocardiograms were reviewed for cardiac dysfunction, defined as left ventricular ejection fraction (EF) <50 % and/or presence of regional wall motion abnormalities. RESULTS: Cardiac dysfunction was present in 74 (30 %) patients. Age, body mass index, EF, and proportion of harvested organs differed significantly between the groups with and without cardiac dysfunction. Among patients receiving serial TTEs, 29 patients had cardiac dysfunction on initial TTE, with 15 (52 %) of these patients demonstrating resolved cardiac dysfunction over time leading to organ harvest. CONCLUSIONS: To our knowledge, the present study is the largest study describing the use of serial TTE and its utilization in adult donors. The prevalence of cardiac dysfunction after adult brain death is high, but given enough time and support, many of these donors have improvement in cardiac function, ultimately leading to transplantation.

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Published In

Neurocrit Care

DOI

EISSN

1556-0961

Publication Date

August 2015

Volume

23

Issue

1

Start / End Page

66 / 71

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Tissue Donors
  • Registries
  • Neurology & Neurosurgery
  • Middle Aged
  • Humans
  • Echocardiography
  • Cross-Sectional Studies
  • Brain Death
  • Adult
 

Citation

APA
Chicago
ICMJE
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Borbely, X. I., Krishnamoorthy, V., Modi, S., Rowhani-Rahbar, A., Gibbons, E., Souter, M. J., & Vavilala, M. S. (2015). Temporal Changes in Left Ventricular Systolic Function and Use of Echocardiography in Adult Heart Donors. Neurocrit Care, 23(1), 66–71. https://doi.org/10.1007/s12028-014-0101-x
Borbely, Xenia I., Vijay Krishnamoorthy, Shan Modi, Ali Rowhani-Rahbar, Edward Gibbons, Michael J. Souter, and Monica S. Vavilala. “Temporal Changes in Left Ventricular Systolic Function and Use of Echocardiography in Adult Heart Donors.Neurocrit Care 23, no. 1 (August 2015): 66–71. https://doi.org/10.1007/s12028-014-0101-x.
Borbely XI, Krishnamoorthy V, Modi S, Rowhani-Rahbar A, Gibbons E, Souter MJ, et al. Temporal Changes in Left Ventricular Systolic Function and Use of Echocardiography in Adult Heart Donors. Neurocrit Care. 2015 Aug;23(1):66–71.
Borbely, Xenia I., et al. “Temporal Changes in Left Ventricular Systolic Function and Use of Echocardiography in Adult Heart Donors.Neurocrit Care, vol. 23, no. 1, Aug. 2015, pp. 66–71. Pubmed, doi:10.1007/s12028-014-0101-x.
Borbely XI, Krishnamoorthy V, Modi S, Rowhani-Rahbar A, Gibbons E, Souter MJ, Vavilala MS. Temporal Changes in Left Ventricular Systolic Function and Use of Echocardiography in Adult Heart Donors. Neurocrit Care. 2015 Aug;23(1):66–71.
Journal cover image

Published In

Neurocrit Care

DOI

EISSN

1556-0961

Publication Date

August 2015

Volume

23

Issue

1

Start / End Page

66 / 71

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Tissue Donors
  • Registries
  • Neurology & Neurosurgery
  • Middle Aged
  • Humans
  • Echocardiography
  • Cross-Sectional Studies
  • Brain Death
  • Adult