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Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model.

Publication ,  Journal Article
Chung, L; Bey, AL; Towers, AJ; Cao, X; Kim, IH; Jiang, Y-H
Published in: Neurobiol Dis
February 2018

Epilepsy is prevalent and often medically intractable in Angelman syndrome (AS). AS mouse model (Ube3am-/p+) shows reduced excitatory neurotransmission but lower seizure threshold. The neural mechanism linking the synaptic dysfunction to the seizure remains elusive. We show that the local circuits of Ube3am-/p+in vitro are hyperexcitable and display a unique epileptiform activity, a phenomenon that is reminiscent of the finding in fragile X syndrome (FXS) mouse model. Similar to the FXS model, lovastatin suppressed the epileptiform activity and audiogenic seizures in Ube3am-/p+. The in vitro model of Ube3am-/p+ is valuable for dissection of neural mechanism and epilepsy drug screening in vivo.

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Published In

Neurobiol Dis

DOI

EISSN

1095-953X

Publication Date

February 2018

Volume

110

Start / End Page

12 / 19

Location

United States

Related Subject Headings

  • Ubiquitin-Protein Ligases
  • Seizures
  • Organ Culture Techniques
  • Neurology & Neurosurgery
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Lovastatin
  • Hippocampus
 

Citation

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Chicago
ICMJE
MLA
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Chung, L., Bey, A. L., Towers, A. J., Cao, X., Kim, I. H., & Jiang, Y.-H. (2018). Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model. Neurobiol Dis, 110, 12–19. https://doi.org/10.1016/j.nbd.2017.10.016
Chung, Leeyup, Alexandra L. Bey, Aaron J. Towers, Xinyu Cao, Il Hwan Kim, and Yong-Hui Jiang. “Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model.Neurobiol Dis 110 (February 2018): 12–19. https://doi.org/10.1016/j.nbd.2017.10.016.
Chung L, Bey AL, Towers AJ, Cao X, Kim IH, Jiang Y-H. Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model. Neurobiol Dis. 2018 Feb;110:12–9.
Chung, Leeyup, et al. “Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model.Neurobiol Dis, vol. 110, Feb. 2018, pp. 12–19. Pubmed, doi:10.1016/j.nbd.2017.10.016.
Chung L, Bey AL, Towers AJ, Cao X, Kim IH, Jiang Y-H. Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model. Neurobiol Dis. 2018 Feb;110:12–19.
Journal cover image

Published In

Neurobiol Dis

DOI

EISSN

1095-953X

Publication Date

February 2018

Volume

110

Start / End Page

12 / 19

Location

United States

Related Subject Headings

  • Ubiquitin-Protein Ligases
  • Seizures
  • Organ Culture Techniques
  • Neurology & Neurosurgery
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Lovastatin
  • Hippocampus