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CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids.

Publication ,  Journal Article
Knisely, MR; Carpenter, JS; Draucker, CB; Skaar, T; Broome, ME; Holmes, AM; Von Ah, D
Published in: Applied nursing research : ANR
December 2017

When codeine and tramadol are used for pain management, it is imperative that nurses are able to assess for potential drug-gene and drug-drug-gene interactions that could adversely impact drug metabolism and ultimately pain relief. Both drugs are metabolized through the CYP2D6 metabolic pathway which can be affected by medications as well the patient's own pharmacogenotype. The purpose of this brief report is to identify drug-gene and drug-drug-gene interactions in 30 adult patients prescribed codeine or tramadol for pain.We used three data sources: (1) six months of electronic health record data on the number and types of medications prescribed to each patient; (2) each patient's CYP2D6 pharmacogenotype, and (3) published data on known CYP2D6 gene-drug and drug-drug-gene interactions.Ten patients (33%) had possible drug-gene or drug-drug-gene interactions. Five patients had CYP2D6 drug-gene interactions indicating they were not good candidates for codeine or tramadol. In addition, five patients had potential CYP2D6 drug-drug-gene interactions with either codeine or tramadol.Our findings from this exploratory study underscores the importance of assessing and accounting for drug-gene and drug-drug-gene interactions in patients prescribed codeine or tramadol.

Duke Scholars

Published In

Applied nursing research : ANR

DOI

EISSN

1532-8201

ISSN

0897-1897

Publication Date

December 2017

Volume

38

Start / End Page

107 / 110

Related Subject Headings

  • Young Adult
  • Tramadol
  • Pharmacogenetics
  • Nursing
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cytochrome P-450 CYP2D6
  • Codeine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Knisely, M. R., Carpenter, J. S., Draucker, C. B., Skaar, T., Broome, M. E., Holmes, A. M., & Von Ah, D. (2017). CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids. Applied Nursing Research : ANR, 38, 107–110. https://doi.org/10.1016/j.apnr.2017.10.001
Knisely, Mitchell R., Janet S. Carpenter, Claire Burke Draucker, Todd Skaar, Marion E. Broome, Ann M. Holmes, and Diane Von Ah. “CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids.Applied Nursing Research : ANR 38 (December 2017): 107–10. https://doi.org/10.1016/j.apnr.2017.10.001.
Knisely MR, Carpenter JS, Draucker CB, Skaar T, Broome ME, Holmes AM, et al. CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids. Applied nursing research : ANR. 2017 Dec;38:107–10.
Knisely, Mitchell R., et al. “CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids.Applied Nursing Research : ANR, vol. 38, Dec. 2017, pp. 107–10. Epmc, doi:10.1016/j.apnr.2017.10.001.
Knisely MR, Carpenter JS, Draucker CB, Skaar T, Broome ME, Holmes AM, Von Ah D. CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids. Applied nursing research : ANR. 2017 Dec;38:107–110.
Journal cover image

Published In

Applied nursing research : ANR

DOI

EISSN

1532-8201

ISSN

0897-1897

Publication Date

December 2017

Volume

38

Start / End Page

107 / 110

Related Subject Headings

  • Young Adult
  • Tramadol
  • Pharmacogenetics
  • Nursing
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cytochrome P-450 CYP2D6
  • Codeine