NCCN Guidelines Insights: Central Nervous System Cancers, Version 1.2017.

Journal Article (Journal Article)

For many years, the diagnosis and classification of gliomas have been based on histology. Although studies including large populations of patients demonstrated the prognostic value of histologic phenotype, variability in outcomes within histologic groups limited the utility of this system. Nonetheless, histology was the only proven and widely accessible tool available at the time, thus it was used for clinical trial entry criteria, and therefore determined the recommended treatment options. Research to identify molecular changes that underlie glioma progression has led to the discovery of molecular features that have greater diagnostic and prognostic value than histology. Analyses of these molecular markers across populations from randomized clinical trials have shown that some of these markers are also predictive of response to specific types of treatment, which has prompted significant changes to the recommended treatment options for grade III (anaplastic) gliomas.

Full Text

Duke Authors

Cited Authors

  • Nabors, LB; Portnow, J; Ammirati, M; Baehring, J; Brem, H; Butowski, N; Fenstermaker, RA; Forsyth, P; Hattangadi-Gluth, J; Holdhoff, M; Howard, S; Junck, L; Kaley, T; Kumthekar, P; Loeffler, JS; Moots, PL; Mrugala, MM; Nagpal, S; Pandey, M; Parney, I; Peters, K; Puduvalli, VK; Ragsdale, J; Rockhill, J; Rogers, L; Rusthoven, C; Shonka, N; Shrieve, DC; Sills, AK; Swinnen, LJ; Tsien, C; Weiss, S; Wen, PY; Willmarth, N; Bergman, MA; Engh, A

Published Date

  • November 2017

Published In

Volume / Issue

  • 15 / 11

Start / End Page

  • 1331 - 1345

PubMed ID

  • 29118226

Electronic International Standard Serial Number (EISSN)

  • 1540-1413

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2017.0166


  • eng

Conference Location

  • United States