Ghrelin and Obesity: Identifying Gaps and Dispelling Myths. A Reappraisal.

Journal Article (Review;Journal Article)

The etiology of obesity is complex. Environmental and genetic causes have been implicated in the development of this disease. Ghrelin is a hormone known to stimulate appetite. There are numerous possible actions through which ghrelin exerts its effect in the body: a) Overproduction of ghrelin, b) reduced ghrelin following meals, and c) increased receptor sensitivity to ghrelin action. Sleeve gastrectomy, a bariatric procedure, leads to reduction of ghrelin levels and subsequently to weight loss. However, there are many limitations to measurement of the fasting plasma level of the active form of ghrelin. The establishment of the exact correlation between ghrelin, appetite and obesity could be vital for the fight against obesity.

Full Text

Duke Authors

Cited Authors

  • Makris, MC; Alexandrou, A; Papatsoutsos, EG; Malietzis, G; Tsilimigras, DI; Guerron, AD; Moris, D

Published Date

  • November 2017

Published In

Volume / Issue

  • 31 / 6

Start / End Page

  • 1047 - 1050

PubMed ID

  • 29102924

Pubmed Central ID

  • PMC5756630

Electronic International Standard Serial Number (EISSN)

  • 1791-7549

International Standard Serial Number (ISSN)

  • 0258-851X

Digital Object Identifier (DOI)

  • 10.21873/invivo.11168


  • eng