Individual, Partner, and Couple Predictors of HIV Infection among Pregnant Women in Malawi: A Case-Control Study.


Journal Article

We aimed to understand drivers of HIV-infection in pregnant women in Malawi. The study was conducted in antenatal and labor and delivery wards. HIV-infected women and their partners (cases) were frequency matched in a 1:2 ratio based on age and screening location to HIV-uninfected women and their partners (controls) in a prevalent case-control study. Characteristics associated with female HIV infection were assessed using logistic regression modeling. At screening, HIV-infected women were more likely to have partners outside Lilongwe than HIV-uninfected women (24% vs. 0%, p < 0.0001). Case females were more likely to have HIV-infected study partners than control females (75% vs. 4%, p < 0.0001). The odds of female HIV-infection were higher if either couple member reported ≥ 2 lifetime marriages (OR 9.0, CI 2.6-30.9) or ≥ 3 lifetime partners (OR 18.0, CI 3.1-103.6) and lower if either reported past couple HIV testing and counseling (OR 0.1, CI 0.04-0.3). Targeting women with migrating partners, promoting couple HIV testing and counseling, and limiting partners could slow HIV transmission.

Full Text

Duke Authors

Cited Authors

  • Rosenberg, NE; Graybill, LA; Wesevich, A; McGrath, N; Golin, CE; Maman, S; Tsidya, M; Chimndozi, L; Hoffman, IF; Hosseinipour, MC; Miller, WC

Published Date

  • June 2018

Published In

Volume / Issue

  • 22 / 6

Start / End Page

  • 1775 - 1786

PubMed ID

  • 29086117

Pubmed Central ID

  • 29086117

Electronic International Standard Serial Number (EISSN)

  • 1573-3254

International Standard Serial Number (ISSN)

  • 1090-7165

Digital Object Identifier (DOI)

  • 10.1007/s10461-017-1947-7


  • eng