The effect of pulmonary surfactant on the in vitro activity of Iclaprim against common respiratory bacterial pathogens.


Journal Article

The in vitro antimicrobial activity of iclaprim, a novel diaminopyrimidine, against common respiratory bacteria remained unchanged in the presence of pulmonary surfactant (Survanta®) at concentrations that greatly antagonized the antimicrobial activity of daptomycin. These results indicate that iclaprim could be a potential treatment for pneumonia caused by susceptible and multidrug resistant bacteria.

Full Text

Duke Authors

Cited Authors

  • Huang, DB; Duncan, LR; Flamm, RK; Dryden, M; Corey, GR; Wilcox, MH; Torres, A; File, TM

Published Date

  • January 2018

Published In

Volume / Issue

  • 90 / 1

Start / End Page

  • 64 - 66

PubMed ID

  • 29103875

Pubmed Central ID

  • 29103875

Electronic International Standard Serial Number (EISSN)

  • 1879-0070

Digital Object Identifier (DOI)

  • 10.1016/j.diagmicrobio.2017.09.011


  • eng

Conference Location

  • United States