Cell Biology of Astrocyte-Synapse Interactions.

Published

Journal Article (Review)

Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of brain development and physiology through dynamic and often bidirectional interactions with neuronal synapses. Despite the clear importance of astrocytes for the establishment and maintenance of proper synaptic connectivity, our understanding of their role in brain function is still in its infancy. We propose that this is at least in part due to large gaps in our knowledge of the cell biology of astrocytes and the mechanisms they use to interact with synapses. In this review, we summarize some of the seminal findings that yield important insight into the cellular and molecular basis of astrocyte-neuron communication, focusing on the role of astrocytes in the development and remodeling of synapses. Furthermore, we pose some pressing questions that need to be addressed to advance our mechanistic understanding of the role of astrocytes in regulating synaptic development.

Full Text

Duke Authors

Cited Authors

  • Allen, NJ; Eroglu, C

Published Date

  • November 1, 2017

Published In

Volume / Issue

  • 96 / 3

Start / End Page

  • 697 - 708

PubMed ID

  • 29096081

Pubmed Central ID

  • 29096081

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2017.09.056

Language

  • eng

Conference Location

  • United States